Article
Clinical relevance of epidermal growth factor receptor (EGFR) alterations in human pancreatic tumors.
Oncology reports - 1 Aug 2011
Lozano-Leon Antonio, Perez-Quintela Begona Vieites, Iglesias-García Julio, Urisarri-Ruiz Adela, Lariño-Noia Jose, Abdulkader Ihab, Varo Evaristo, Forteza Jeronimo, Domínguez-Muñoz J Enrique
Abstract excerpt
Pancreatic cancer is a malignant neoplasm with an extremely poor prognosis. The mechanisms of aggressive growth and metastasis are currently not well understood. Expression of epidermal growth factor receptor (EGFR) has been suggested to be associated with the malignant transformation of pancreatic cancer. In this study, we examined the EGFR status of 52 pancreatic tumors by PCR-sequencing (exons 19 and 21),...
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