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Article

Association of glucocorticoid receptor polymorphism A3669G in exon 9beta with reduced central adiposity in women.

Obesity (Silver Spring, Md.) - 1 May 2006

Syed Akheel A, Irving Julie A E, Redfern Christopher P F, Hall Andrew G, Unwin Nigel C, White Martin, Bhopal Raj S, Weaver Jolanta U

Abstract excerpt

The glucocorticoid receptor (GR) may be a common link between human obesity/metabolic syndrome and Cushing's syndrome. The effects of glucocorticoids are mediated through the functional isoform, GRalpha. An alternative isoform, GRbeta, behaves as a dominant negative inhibitor of GRalpha and has been implicated as a contributing factor to glucocorticoid resistance. A naturally occurring ATTTA to GTTTA single...

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Identifiers

PMID: 16855182
DOI: 10.1038/oby.2006.86

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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