Article
PAI-1 plasma levels in a general population without clinical evidence of atherosclerosis: relation to environmental and genetic determinants.
Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 1998
Margaglione M, Cappucci G, d'Addedda M, Colaizzo D, Giuliani N, Vecchione G, Mascolo G, Grandone E, Di Minno G
Abstract excerpt
Plasminogen activator inhibitor-1 (PAI-1) plasma levels have been consistently related to a polymorphism (4G/5G) of the PAI-1 gene. The renin-angiotensin pathway plays a role in the regulation of PAI-1 plasma levels. An insertion (I)/deletion (D) polymorphism of the angiotensin-converting enzyme...
Topics
- Adult
- Aged
- Aging
- Alcohol Drinking
- Body Mass Index
- Cholesterol
- Female
- Gene Deletion
- Gene Frequency
- Genotype
- Humans
- Hypertension
- Male
- Middle Aged
- Peptidyl-Dipeptidase A
- Plasminogen Activator Inhibitor 1
- Polymorphism, Genetic
- Sex Characteristics