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Article

Mutations in the BMP pathway in mice support the existence of two molecular classes of holoprosencephaly.

Development (Cambridge, England) - 1 Nov 2007

Fernandes Marie, Gutin Grigoriy, Alcorn Heather, McConnell Susan K, Hébert Jean M

Abstract excerpt

Holoprosencephaly (HPE) is a devastating forebrain abnormality with a range of morphological defects characterized by loss of midline tissue. In the telencephalon, the embryonic precursor of the cerebral hemispheres, specialized cell types form a midline that separates the hemispheres. In the present study, deletion of the BMP receptor genes, Bmpr1b and Bmpr1a, in the mouse telencephalon results in a loss of all...

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Share to Bone Morphogenetic Protein Receptors, Type I
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17913790
DOI: 10.1242/dev.004325

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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