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Article

Mouse models of holoprosencephaly.

Current opinion in neurology - 1 Apr 2003

Hayhurst Monica, McConnell Susan K

Abstract excerpt

PURPOSE OF REVIEW: Holoprosencephaly (HPE) is the most common anomaly of forebrain development in humans. The pathogenesis of HPE results in a failure of the brain hemispheres to separate during early development. Here we review experimental models of HPE in which some of the genes known to cause HPE in humans have been disrupted in the mouse. RECENT FINDINGS: To date, mutations that cause HPE have been...

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Source

Identifiers

PMID: 12644739
DOI: 10.1097/01.wco.0000063761.15877.40

Genes

SHH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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