Article
Noggin null allele mice exhibit a microform of holoprosencephaly.
Human molecular genetics - 15 Oct 2011
Lana-Elola Eva, Tylzanowski Przemko, Takatalo Maarit, Alakurtti Kirsi, Veistinen Lotta, Mitsiadis Thimios A, Graf Daniel, Rice Ritva, Luyten Frank P, Rice David P
Abstract excerpt
Holoprosencephaly (HPE) is a heterogeneous craniofacial and neural developmental anomaly characterized in its most severe form by the failure of the forebrain to divide. In humans, HPE is associated with disruption of Sonic hedgehog and Nodal signaling pathways, but the role of other signaling pathways has not yet been determined. In this study, we analyzed mice which, due to the lack of the Bmp antagonist...
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