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Article

Function of the MAPK scaffold protein, Ste5, requires a cryptic PH domain.

Genes & development - 15 Jul 2006

Garrenton Lindsay S, Young Susan L, Thorner Jeremy

Abstract excerpt

Ste5, the prototypic mitogen-activated protein kinase (MAPK) scaffold protein, associates with plasma membrane-tethered Gbetagamma freed upon pheromone receptor occupancy, thereby initiating downstream signaling. We demonstrate that this interaction and membrane binding of an N-terminal amphipathic alpha-helix (PM motif) are not sufficient for Ste5 action. Rather, Ste5 contains a pleckstrin-homology (PH) domain...

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Source

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Identifiers

PMID: 16847350
DOI: 10.1101/gad.1413706
PMCID: PMC1522084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Function of the MAPK scaffold protein, Ste5, requires a cryptic PH domain.PMID 16847350Read ↗

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