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Article

Characterization of Glycoproteoforms of Integrins α2 and β1 in Megakaryocytes in the Occurrence of JAK2V617F Mutation-Induced Primary Myelofibrosis.

Molecular & cellular proteomics : MCP - 1 Apr 2022

Gaye Maissa M, Ward Christina M, Piasecki Andrew J, Stahl Vanessa L, Karagianni Aikaterini, Costello Catherine E, Ravid Katya

Abstract excerpt

Primary myelofibrosis (PMF) is a neoplasm prone to leukemic transformation, for which limited treatment is available. Among individuals diagnosed with PMF, the most prevalent mutation is the JAK2V617F somatic point mutation that activates the Janus kinase 2 (JAK2) enzyme. Our earlier reports on hyperactivity of β1 integrin and enhanced adhesion activity of the α2β1 complex in JAK2V617F megakaryocytes (MKs) led us...

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Identifiers

PMID: 35182768
DOI: 10.1016/j.mcpro.2022.100213
PMCID: PMC8968581

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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