Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability.

The Journal of biological chemistry - 18 Aug 2000

Ishida N, Kitagawa M, Hatakeyama S, Nakayama K

Abstract excerpt

The association of the p27(Kip1) protein with cyclin and cyclin-dependent kinase complexes inhibits their kinase activities and contributes to the control of cell proliferation. The p27(Kip1) protein has now been shown to be phosphorylated in vivo, and this phosphorylation reduces the electrophoretic mobility of the protein. Substitution of Ser(10) with Ala (S10A) markedly reduced the extent of p27(Kip1)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to Alkaline Phosphatase
Share to Cyclin-Dependent Kinase Inhibitor p27

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophoresis, Gel, Two-Dimensional

Share to G1 Phase

Share to Peptide Mapping

Share to Precipitin Tests

Share to Resting Phase, Cell Cycle

Source

Identifiers

PMID: 10831586
DOI: 10.1074/jbc.M001144200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability.PMID 10831586Read ↗

Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation.Semantic proximity Read ↗

Mutations of phosphorylation sites Ser10 and Thr187 of p27Kip1 abolish cytoplasmic redistribution but do not abrogate G0/1 phase arrest in the HepG2 cell line.Semantic proximity Read ↗

p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis.Semantic proximity Read ↗

The function of p27 KIP1 during tumor development.Semantic proximity Read ↗

A cancer‐associated CDKN1B mutation induces p27 phosphorylation on a novel residue: a new mechanism for tumor suppressor loss‐of‐functionSemantic proximity Read ↗

The cyclin-dependent kinase inhibitor p27Kip1 is stabilized in G(0) by Mirk/dyrk1B kinase.Semantic proximity Read ↗

Understanding p27<sup>kip1</sup>Deregulation in Cancer: Downregulation or Mislocalizaiton?Semantic proximity Read ↗

Mutant p27(Kip1) and its potential effect as hepatocellular gene therapy.Semantic proximity Read ↗

High level expression of p27 <sup>kip1</sup> and cyclin D1 in some human breast cancer cells: Inverse correlation between the expression of p27 <sup>kip1</sup> and degree of malignancy in human breast and colorectal cancersSemantic proximity Read ↗

Phosphorylation of p27Kip1 at Thr187 by cyclin-dependent kinase 5 modulates neural stem cell differentiation.Semantic proximity Read ↗

Transfection of p27(Kip1) threonine residue 187 mutant type gene, which is not influenced by ubiquitin-mediated degradation, induces cell cycle arrest in oral squamous cell carcinoma cells.Semantic proximity Read ↗

Molecular characterization of the cyclin-dependent kinase inhibitor p27 promoter.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.