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Article

GTP in the mitochondrial matrix plays a crucial role in organellar iron homoeostasis.

The Biochemical journal - 15 Nov 2006

Gordon Donna M, Lyver Elise R, Lesuisse Emmanuel, Dancis Andrew, Pain Debkumar

Abstract excerpt

Mitochondria are the major site of cellular iron utilization for the synthesis of essential cofactors such as iron-sulfur clusters and haem. In the present study, we provide evidence that GTP in the mitochondrial matrix is involved in organellar iron homoeostasis. A mutant of yeast Saccharomyces cerevisiae lacking the mitochondrial GTP/GDP carrier protein (Ggc1p) exhibits decreased levels of matrix GTP and...

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Identifiers

PMID: 16842238
DOI: 10.1042/BJ20060904
PMCID: PMC1635451

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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