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Article

Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity.

The Journal of biological chemistry - 12 Nov 1999

Zenke F T, King C C, Bohl B P, Bokoch G M

Abstract excerpt

p21-activated kinases (Pak)/Ste20 kinases are regulated in vitro and in vivo by the small GTP-binding proteins Rac and Cdc42 and lipids, such as sphingosine, which stimulate autophosphorylation and phosphorylation of exogenous substrates. The mechanism of Pak activation by these agents remains unclear. We investigated Pak kinase activation in more detail to gain insight into the interplay between the...

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Source

Identifiers

PMID: 10551809
DOI: 10.1074/jbc.274.46.32565

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity.PMID 10551809Read ↗

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