Article
Identification of an autoinhibitory domain of p21-activated protein kinase 5.
The Journal of biological chemistry - 5 Sept 2003
Ching Yick-Pang, Leong Veronica Y L, Wong Chi-Ming, Kung Hsiang-Fu
Abstract excerpt
The p21-activated protein kinases (Paks) are serine/threonine protein kinases activated by binding to Rho family small GTPases, Rac and Cdc42. Recently, Pak family members have been subdivided into two groups, I and II. Group II Paks, including Pak4, Pak5, and Pak6, does not contain the highly conserved autoinhibitory domain that is found in the group I Paks members, i.e. Pak1, Pak2, and Pak3. In the present...
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