Article
[Genetic polymorphism of the metabolism of drugs used in cardiac diseases].
Archives des maladies du coeur et des vaisseaux - 1 Sept 1991
Funck-Brentano C
Abstract excerpt
The genetic determinants of the metabolism of certain drugs used in cardiology is one predictable cause of variability in their pharmacokinetics and effects. Genetic polymorphism of the metabolism of drugs is characterised by the existence of several metabolic phenotypes, usually 2, which allow distinction between fast and slow metabolisers. Clinical identification of these phenotypes is relatively simple. The...
Topics
- Acetyltransferases
- Adrenergic beta-Antagonists
- Anti-Arrhythmia Agents
- Cardiovascular Agents
- Cytochrome P-450 Enzyme System
- Drug Interactions
- Humans
- Perhexiline
- Pharmacogenetics
- Phenotype
- Polymorphism, Genetic