Article
[The polymorphism of pachycarpine oxidation].
Eksperimental'naia i klinicheskaia farmakologiia - 1 Jan 2000
Piotrovskiĭ V K, Belolipetskaia V G, Rumiantsev D O, Metelitsa V I
Abstract excerpt
The ratio of urinary excretory pachycarpine to its oxidized metabolites, 2- and 5-dehydropachycarpines (metabolic ratio) was determined in a selective group of 81 unrelated cardiac patients from a Moscow Caucasian population given pachycarpine in a dose of 25 g. The metabolic ratio distribution was shown to be bimodal. Ninety five per cent of the patients had the metabolic ratio lower than 28 while 4 (5%)...
Topics
- Adult
- Chromatography, Gas
- Chronic Disease
- Drug Interactions
- Humans
- Hypertension
- Male
- Middle Aged
- Myocardial Ischemia
- Oxidation-Reduction
- Phenotype
- Polymorphism, Genetic