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ErbB/HER family in cancer immunology: therapeutic advances and mechanisms

24 Jul 2025

Abstract excerpt

The ErbB/HER family has a crucial role in tumor progression and immune responses, offering promising targets for cancer drug discovery. In particular, ErbB/HER-targeted therapeutic agents, in the forms of tyrosine kinase inhibitors (TKIs), monoclonal/bispecific antibodies (mAbs/BsAbs), and antibody-drug conjugates (ADCs), have emerged as effective therapeutic options to achieve excellent clinical outcomes by...

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PMID: 40714206
DOI: 10.1016/j.drudis.2025.104436

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