Article
Association between IL-18 gene promoter polymorphisms and inflammatory bowel disease in a Japanese population.
Inflammatory bowel diseases - 1 Dec 2005
Takagawa T, Tamura K, Takeda N, Tomita T, Ohda Y, Fukunaga K, Hida N, Ohnishi K, Hori K, Kosaka T, Fukuda Y, Ikeuchi H, Yamamura T, Miwa H, Matsumoto T
Abstract excerpt
BACKGROUND: Interleukin-18 (IL-18) is a pleiotropic cytokine that induces the production of interferon (IFN)-gamma and also to regulate Th2 cytokines. Recently, association studies between IL-18 gene promoter polymorphisms and several Th1- or Th2-mediated inflammatory diseases were reported. In inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), recent evidence suggests...
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