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Article

A376S in the connection subdomain of HIV-1 reverse transcriptase confers increased risk of virological failure to nevirapine therapy.

The Journal of infectious diseases - 1 Sept 2011

Paredes Roger, Puertas Maria Carmen, Bannister Wendy, Kisic Mónica, Cozzi-Lepri Alessandro, Pou Christian, Bellido Rocío, Betancor Gilberto, Bogner Johannes, Gargalianos Panagiotis, Bánhegyi Dénes, Clotet Bonaventura, Lundgren Jens, Menéndez-Arias Luis, Martinez-Picado Javier

Abstract excerpt

BACKGROUND: The clinical relevance of mutations in the connection subdomain and the ribonuclease (RNase) H domain of HIV-1 reverse transcriptase (RT) is uncertain. METHODS: The risk of virological failure to nonnucleoside RT inhibitor (NNRTI)-based antiretroviral therapy (ART) was evaluated in NNRTI-naive patients who started NNRTIs in the EuroSIDA study after July 1997 according to preexisting substitutions in...

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Identifiers

PMID: 21844300
DOI: 10.1093/infdis/jir385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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A376S in the connection subdomain of HIV-1 reverse transcriptase confers increased risk of virological failure to nevirapine therapy.PMID 21844300Read ↗

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