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Article

The risks and incidence of K65R and L74V mutations and subsequent virologic responses.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Jan 2008

Waters Laura, Nelson Mark, Mandalia Sundhiya, Bower Mark, Powles Tom, Gazzard Brian, Stebbing Justin

Abstract excerpt

The L74V and K65R mutations confer resistance to several nucleoside analogues, and the impact on subsequent regimens is unclear. The risk of developing L74V or K65R mutation in the era of highly active antiretroviral therapy (HAART) was 4.5 and 2.8 cases per 100 person-years, respectively; concomitant receipt of boosted protease inhibitors protected against K65R. High rates of virologic suppression in the...

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Identifiers

PMID: 18171220
DOI: 10.1086/523001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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