Modelling the development of resistance of Plasmodium falciparum to anti-malarial drugs.

doi:10.1016/0035-9203(91)90286-8

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Article

Modelling the development of resistance of Plasmodium falciparum to anti-malarial drugs.

Transactions of the Royal Society of Tropical Medicine and Hygiene - 1 Jan 2000

Cross A P, Singer B

Abstract excerpt

A hybrid transmission/genetics model for the development of resistance by Plasmodium falciparum to anti-malarial drugs is set forth. Field data on pyrimethamine resistance are used to calibrate and test the model. Simulated consequences of different drug dosage and population coverage strategies...

Topics

Adolescent
Adult
Animals
Antimalarials
Child
Child, Preschool
Culicidae
Drug Resistance
Humans
Infant
Malaria
Mathematics
Models, Genetic
Mutation
Plasmodium falciparum
Transformation, Genetic

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