Article
Drug coverage in treatment of malaria and the consequences for resistance evolution--evidence from the use of sulphadoxine/pyrimethamine.
Malaria journal - 5 Jul 2010
Malisa Allen L, Pearce Richard J, Abdulla Salim, Mshinda Hassan, Kachur Patrick S, Bloland Peter, Roper Cally
Abstract excerpt
BACKGROUND: It is argued that, the efficacy of anti-malarials could be prolonged through policy-mediated reductions in drug pressure, but gathering evidence of the relationship between policy, treatment practice, drug pressure and the evolution of resistance in the field is challenging. Mathematical models indicate that drug coverage is the primary determinant of drug pressure and the driving force behind the...
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