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Article

Regulation of asparagine synthetase gene expression by amino acid starvation.

Molecular and cellular biology - 1 Dec 1991

Gong S S, Guerrini L, Basilico C

Abstract excerpt

We have studied the regulation of expression of the asparagine synthetase (AS) gene in ts11 cells, a mutant of BHK hamster cells which encodes a temperature-sensitive AS and therefore does not produce endogenous asparagine at 39.5 degrees C. Incubation of ts11 cells at the nonpermissive temperature drastically increases the level of AS mRNA, and the stimulation of AS mRNA expression is effectively suppressed by...

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Identifiers

PMID: 1682798
DOI: 10.1128/mcb.11.12.6059-6066.1991
PMCID: PMC361776

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Source receipt: pubmed, retrieved 7 Sept 2026.

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