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Article

Amino acid control of asparagine synthetase: relation to asparaginase resistance in human leukemia cells

1 May 1997

Abstract excerpt

Complete amino acid deprivation in mammalian cells causes a significant enhancement in gene expression for a number of important cellular activities; among these is asparagine synthetase (AS). The data presented demonstrate that, in both nonleukemic (rat Fao hepatoma cells) and human leukemia cells (MOLT-4, NALL-1, and BALL-1), AS mRNA levels, protein content, and enzymatic activity are induced after incubation...

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PMID: 9176161
DOI: 10.1152/ajpcell.1997.272.5.c1691

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Amino acid control of asparagine synthetase: relation to asparaginase resistance in human leukemia cellsPMID 9176161Read ↗

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