A mammalian temperature-sensitive mutation affecting G1 progression results from a single amino acid substitution in asparagine synthetase.

doi:10.1093/nar/18.12.3509

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Article

A mammalian temperature-sensitive mutation affecting G1 progression results from a single amino acid substitution in asparagine synthetase.

Nucleic acids research - 25 Jun 1990

Gong S S, Basilico C

Abstract excerpt

ts11 is a temperature-sensitive (ts) mutant isolated from the BHK-21 Syrian hamster cell line that is blocked in the G1 phase of the cell cycle at the non-permissive temperature (39.5 degrees C). We previously showed that the human gene encoding asparagine synthetase (AS) transformed ts11 cells t...

Topics

Amino Acid Sequence
Animals
Aspartate-Ammonia Ligase
Base Sequence
Cell Line
Cloning, Molecular
Cricetinae
DNA
Interphase
Kinetics
Ligases
Molecular Sequence Data
Mutation
Phenotype
Temperature
Transformation, Genetic

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