The insertion of a full-length Bos taurus LINE element is responsible for a transcriptional deregulation of the Normande Agouti gene.

doi:10.1111/j.1600-0749.2006.00312.x

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Article

The insertion of a full-length Bos taurus LINE element is responsible for a transcriptional deregulation of the Normande Agouti gene.

Pigment cell research - 1 Aug 2006

Girardot Michael, Guibert Sylvain, Laforet Marie-Pierre, Gallard Yves, Larroque Hélène, Oulmouden Ahmad

Abstract excerpt

Mammalian pigmentation is controlled by the concerted action of Tyr, Tyrp1 and Dct producing eumelanin and/or pheomelanin in melanocytes. The ratio of these two pigments is determined by the agonist alpha-melanocyte stimulating hormone and the antagonist Agouti protein acting on the Mc1r. Here we show that the Agouti gene is over-expressed in Normande breed compared with Prim'Holstein breed. The Normande cattle...

Topics

Agouti Signaling Protein
Alleles
Animals
Breeding
Cattle
Crosses, Genetic
Gene Expression Profiling
Genotype
Intercellular Signaling Peptides and Proteins
Long Interspersed Nucleotide Elements

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Molecular Sequence Data

Mutagenesis, Insertional

Mutation

Oxidoreductases

Promoter Regions, Genetic

Sequence Homology, Nucleic Acid

Skin Pigmentation

Source

Open in PubMed

Identifiers

PMID: 16827753
DOI: 10.1111/j.1600-0749.2006.00312.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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