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Genomic Analysis Revealed a Convergent Evolution of LINE-1 in Coat Color: A Case Study in Water Buffaloes (Bubalus bubalis).

Molecular biology and evolution - 9 Mar 2021

Liang Dong, Zhao Pengju, Si Jingfang, Fang Lingzhao, Pairo-Castineira Erola, Hu Xiaoxiang, Xu Qing, Hou Yali, Gong Yu, Liang Zhengwen, Tian Bing, Mao Huaming, Yindee Marnoch, Faruque Md Omar, Kongvongxay Siton, Khamphoumee Souksamlane, Liu George E, Wu Dong-Dong, Barker James Stuart F, Han Jianlin, Zhang Yi

Abstract excerpt

Visible pigmentation phenotypes can be used to explore the regulation of gene expression and the evolution of coat color patterns in animals. Here, we performed whole-genome and RNA sequencing and applied genome-wide association study, comparative population genomics and biological experiments to show that the 2,809-bp-long LINE-1 insertion in the ASIP (agouti signaling protein) gene is the causative mutation for...

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PMID: 33212507
DOI: 10.1093/molbev/msaa279
PMCID: PMC7947781

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genomic Analysis Revealed a Convergent Evolution of LINE-1 in Coat Color: A Case Study in Water Buffaloes (Bubalus bubalis).PMID 33212507Read ↗

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