Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Essential role of STAT3 in postnatal survival and growth revealed by mice lacking STAT3 serine 727 phosphorylation.

Molecular and cellular biology - 1 Jan 2004

Shen Yuhong, Schlessinger Karni, Zhu Xuejun, Meffre Eric, Quimby Fred, Levy David E, Darnell J E

Abstract excerpt

A large number of extracellular polypeptides bound to their cognate receptors activate the transcription factor STAT3 by phosphorylation of tyrosine 705. Supplemental activation occurs when serine 727 is also phosphorylated. STAT3 deletion in mice leads to embryonic lethality. We have produced mi...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fibroblasts
Share to Genes, Lethal
Share to Genes, Recessive

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin-Like Growth Factor I

Share to Serine

Share to STAT3 Transcription Factor

Share to Thymus Gland

Share to Trans-Activators

Source

Open in PubMed Open full text

Identifiers

PMID: 14673173
DOI: 10.1128/MCB.24.1.407-419.2004
PMCID: PMC303338

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14673173-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Essential role of STAT3 in postnatal survival and growth revealed by mice lacking STAT3 serine 727 phosphorylation.PMID 14673173Read ↗

STAT3 positively regulates an early step in B-cell development.Semantic proximity Read ↗

STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation.Semantic proximity Read ↗

Suppression of STAT5 functions in liver, mammary glands, and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice.Semantic proximity Read ↗

The STAT3 isoforms alpha and beta have unique and specific functions.Semantic proximity Read ↗

Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras.Semantic proximity Read ↗

Serine Phosphorylation of the STAT1 Transactivation Domain Promotes Autoreactive B Cell and Systemic Autoimmunity DevelopmentSemantic proximity Read ↗

Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation [correction of activation] in the liver.Semantic proximity Read ↗

Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.Semantic proximity Read ↗

Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction.Semantic proximity Read ↗

Y705 and S727 are required for the mitochondrial import and transcriptional activities of STAT3, and for regulation of stem cell proliferation.Semantic proximity Read ↗

Zebrafishstat3 is expressed in restricted tissues during embryogenesis andstat1 rescues cytokine signaling in aSTAT1-deficient human cell lineSemantic proximity Read ↗

Interleukin 4 Regulates Phosphorylation of Serine 756 in the Transactivation Domain of Stat6Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.