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Article

Overexpression of a dominant negative form of STAT3 selectively impairs hematopoietic stem cell activity.

Oncogene - 18 Jul 2002

Oh Il-Hoan, Eaves Connie J

Abstract excerpt

STAT3 is a key downstream signaling intermediate of gp130, a receptor previously shown to activate hematopoietic stem cell (HSC) self-renewal divisions. These findings prompted us to investigate if the STAT3 pathway is important to HSC activity in vivo. Initial semi-quantitative RT-PCR analyses showed STAT3 to be expressed at slightly higher levels in primitive subsets of both human and murine adult bone marrow...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12101416
DOI: 10.1038/sj.onc.1205592

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Overexpression of a dominant negative form of STAT3 selectively impairs hematopoietic stem cell activity.PMID 12101416Read ↗

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