Variation in T-lymphocyte activation and susceptibility to SIVPBj-14-induced acute death in macaques.

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Article

Variation in T-lymphocyte activation and susceptibility to SIVPBj-14-induced acute death in macaques.

Journal of medical primatology - 1 Jun 1991

Rosenberg Y J, White B D, Papermaster S F, Zack P, Jarling P B, Eddy G A, Burke D S, Lewis M G

Abstract excerpt

In contrast to pig-tailed and cynomolgus macaques, which die in 6-10 days following infection with the SIV-PBj-14 isolate, only about 50% of rhesus succumbed to rapid disease. Using a CD45RA MAb that delineates memory (CD45RAlo), naive (CD45RAmed) and "activated" (CD45RAhi) T-cell subsets, it was seen that PBMC from pig-tailed and cynomolgus monkeys, unlike rhesus, have reduced CD4/CD8 ratios and a skewing of T...

Topics

Acute Disease
Animals
Antigens, CD
CD4-Positive T-Lymphocytes
Disease Susceptibility
Histocompatibility Antigens
Leukocyte Common Antigens
Lymphocyte Activation
Macaca
Macaca fascicularis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Macaca mulatta

Macaca nemestrina

Phenotype

Simian Acquired Immunodeficiency Syndrome

Simian Immunodeficiency Virus

T-Lymphocytes

T-Lymphocytes, Regulatory

Source

Open in PubMed

Identifiers

PMID: 1682498

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1682498-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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