Article
A genome rearrangement has orphaned the Escherichia coli K-12 AcpT phosphopantetheinyl transferase from its cognate Escherichia coli O157:H7 substrates.
Molecular microbiology - 1 Jul 2006
De Lay Nicholas R, Cronan John E
Abstract excerpt
Phosphopantetheinyl transferases (PPTases) are enzymes that catalyse the transfer of a 4'-phosphopantetheine moiety from CoA to a conserved serine residue of a carrier protein. These carrier proteins use the 4'-phosphopantetheine thiol to shuttle intermediates between the active sites of biosynthetic enzymes involved in fatty acid, non-ribosomal peptide and polyketide synthesis. Three PPTases have been previously...
Topics
- Acyl Carrier Protein
- Bacterial Proteins
- Base Sequence
- Chromosome Mapping
- Chromosomes, Bacterial
- Cloning, Molecular
- Escherichia coli
- Escherichia coli O157
- Escherichia coli Proteins
- Genetic Complementation Test