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Article

Biosynthesis of inner core lipopolysaccharide in enteric bacteria identification and characterization of a conserved phosphoheptose isomerase.

The Journal of biological chemistry - 16 Feb 1996

Brooke J S, Valvano M A

Abstract excerpt

The lpcA locus has been identified in Escherichia coli K12 novobiocin-supersensitive mutants that produce a short lipopolysaccharide (LPS) core which lacks glyceromannoheptose and terminal hexoses. We have characterized lpcA as a single gene mapping around 5.3 min (246 kilobases) on the E. coli K12 chromosome and encoding a 22.6-kDa cytosolic protein. Recombinant plasmids containing only lpcA restored a complete...

Topics

Aldose-Ketose Isomerases
Amino Acid Sequence
Animals
Base Sequence
Carbohydrate Epimerases
Carbohydrate Metabolism
Carbohydrates
Chromatography, High Pressure Liquid
Chromosome Deletion
Chromosomes, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Conserved Sequence

Enterobacteriaceae

Escherichia coli

Genes, Bacterial

Genotype

Lipopolysaccharides

Molecular Sequence Data

Rats

Source

Identifiers

PMID: 8631969
DOI: 10.1074/jbc.271.7.3608

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8631969-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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