Article
Two site-directed mutations are required for the conversion of a sugar dehydratase into an aminotransferase.
Biochemistry - 16 Jun 2009
Cook Paul D, Kubiak Rachel L, Toomey Daniel P, Holden Hazel M
Abstract excerpt
L-colitose and d-perosamine are unusual sugars found in the O-antigens of some Gram-negative bacteria such as Escherichia coli, Vibrio cholerae, and Salmonella enterica, among others. The biosynthetic pathways for these two sugars begin with the formation of GDP-mannose from d-mannose 1-phosphate and GTP followed by the subsequent dehydration and oxidation of GDP-mannose to yield GDP-4-keto-6-deoxymannose....
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