Article
Interplay between siderophores and colibactin genotoxin biosynthetic pathways in Escherichia coli.
PLoS pathogens - 1 Jan 2013
Martin Patricia, Marcq Ingrid, Magistro Giuseppe, Penary Marie, Garcie Christophe, Payros Delphine, Boury Michèle, Olier Maïwenn, Nougayrède Jean-Philippe, Audebert Marc, Chalut Christian, Schubert Sören, Oswald Eric
Abstract excerpt
In Escherichia coli, the biosynthetic pathways of several small iron-scavenging molecules known as siderophores (enterobactin, salmochelins and yersiniabactin) and of a genotoxin (colibactin) are known to require a 4'-phosphopantetheinyl transferase (PPTase). Only two PPTases have been clearly identified: EntD and ClbA. The gene coding for EntD is part of the core genome of E. coli, whereas ClbA is encoded on the...
Topics
- Animals
- Bacterial Proteins
- Enterobactin
- Escherichia coli
- Escherichia coli Infections
- Escherichia coli Proteins
- Female
- Gene Deletion
- Genomic Islands
- Glycopeptides