Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Crucial Mitochondrial Impairment upon CDC48 Mutation in Apoptotic Yeast

6 Jul 2006

Abstract excerpt

Mutation in CDC48 (cdc48(S565G)), a gene essential in the endo-plasmic reticulum (ER)-associated protein degradation (ERAD) pathway, led to the discovery of apoptosis as a mechanism of cell death in the unicellular organism Saccharomyces cerevisiae. Elucidating Cdc48p-mediated apoptosis in yeast is of particular interest, because Cdc48p is the highly conserved yeast orthologue of human valosin-containing protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Endoplasmic Reticulum Stress and Disease
Share to Mitochondrial Function and Pathology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16822868
DOI: 10.1074/jbc.m513699200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Crucial Mitochondrial Impairment upon CDC48 Mutation in Apoptotic YeastPMID 16822868Read ↗

Mechanisms of Cdc48/VCP-mediated cell death: from yeast apoptosis to human disease.Semantic proximity Read ↗

Inactivation of Cdc13p triggers MEC1-dependent apoptotic signals in yeast.Semantic proximity Read ↗

ATPase activity of p97/valosin-containing protein is regulated by oxidative modification of the evolutionally conserved cysteine 522 residue in Walker A motif.Semantic proximity Read ↗

Cell-cycle involvement in autophagy and apoptosis in yeastSemantic proximity Read ↗

Cadmium induces a heterogeneous and caspase-dependent apoptotic response in Saccharomyces cerevisiae.Semantic proximity Read ↗

Apoptotic death of ageing yeastSemantic proximity Read ↗

Oxidative Stress in Alzheimer's and Parkinson's Diseases: Insights from the YeastSaccharomyces cerevisiaeSemantic proximity Read ↗

Yeast as a tool to study Bax/mitochondrial interactions in cell deathSemantic proximity Read ↗

Yeast cell cycle protein CDC48p shows full-length homology to the mammalian protein VCP and is a member of a protein family involved in secretion, peroxisome formation, and gene expression.Semantic proximity Read ↗

Mitochondrial membrane remodelling regulated by a conserved rhomboid protease.Semantic proximity Read ↗

Phospholipid Scramblase Activity of VDAC Dimers: New Implications for Cell Death, Autophagy and AgeingSemantic proximity Read ↗

A non-death role of the yeast metacaspase: Yca1p alters cell cycle dynamics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.