Article
Cadmium induces a heterogeneous and caspase-dependent apoptotic response in Saccharomyces cerevisiae.
Apoptosis : an international journal on programmed cell death - 1 Jun 2008
Nargund Amrita M, Avery Simon V, Houghton John E
Abstract excerpt
The toxic metal cadmium is linked to a series of degenerative disorders in humans, in which Cd-induced programmed cell death (apoptosis) may play a role. The yeast, Saccharomyces cerevisiae, provides a valuable model for elucidating apoptosis mechanisms, and this study extends that capability to Cd-induced apoptosis. We demonstrate that S. cerevisiae undergoes a glucose-dependent, programmed cell death in...
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