Article
Yeast cell cycle protein CDC48p shows full-length homology to the mammalian protein VCP and is a member of a protein family involved in secretion, peroxisome formation, and gene expression.
The Journal of cell biology - 1 Aug 1991
Fröhlich K U, Fries H W, Rüdiger M, Erdmann R, Botstein D, Mecke D
Abstract excerpt
Yeast mutants of cell cycle gene cdc48-1 arrest as large budded cells with microtubules spreading aberrantly throughout the cytoplasm from a single spindle plaque. The gene was cloned and disruption proved it to be essential. The CDC48 sequence encodes a protein of 92 kD that has an internal duplication of 200 amino acids and includes a nucleotide binding consensus sequence. Vertebrate VCP has a 70% identity over...
Topics
- Adenosine Triphosphatases
- Amino Acid Sequence
- Base Sequence
- Blotting, Western
- Cell Cycle
- Cell Cycle Proteins
- Cloning, Molecular
- DNA, Fungal
- Fungal Proteins
- Gene Expression