Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorder.

doi:10.1002/ajmg.b.30303

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Article

Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorder.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jun 2006

Barden Nicholas, Harvey Mario, Gagné Bernard, Shink Eric, Tremblay Monique, Raymond Catherine, Labbé Michel, Villeneuve André, Rochette Denis, Bordeleau Lise, Stadler Herbert, Holsboer Florian, Müller-Myhsok Bertram

Abstract excerpt

Previous results from our genetic analyses using pedigrees from a French Canadian population suggested that the interval delimited by markers on chromosome 12, D12S86 and D12S378, was the most probable genomic region to contain a susceptibility gene for affective disorders. Association studies with microsatellite markers using a case/control sample from the same population (n = 427) revealed significant allelic...

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PMID: 16673375
DOI: 10.1002/ajmg.b.30303

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