Article
Is multidrug resistance relevant in breast cancer?
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology - 1 Oct 1991
Wishart G C, Kaye S B
Abstract excerpt
The multidrug resistance phenotype is associated with expression of P-glycoprotein (P-gp), an energy-dependent drug efflux pump. P-gp is expressed in several clinically resistant human cancers. This article discusses the evidence that P-gp expression may be implicated in the development of clinical drug resistance in patients with breast cancer.
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Antineoplastic Agents
- Breast Neoplasms
- Drug Resistance
- Female
- Humans
- Membrane Glycoproteins
- Neoplasm Proteins
- Phenotype