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Article

Relevance of multidrug resistance in the age of targeted therapy.

Current opinion in drug discovery & development - 1 Mar 2009

Türk Dóra, Szakács Gergely

Abstract excerpt

Targeted drugs inhibit specific pathways that contribute to the malignant phenotype of cancer cells. The initial success of molecularly targeted therapies raised hope that newly developed agents would evade the general mechanisms of resistance that have reduced the efficacy of traditional anticancer drugs. In recent years, ATP-binding cassette (ABC) transporters related to multidrug resistance (MDR), such as...

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Source

Identifiers

PMID: 19333870

Genes

ABCB1
ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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