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Article

Multidrug Resistance in Breast Cancer: From<i>In Vitro</i>Models to Clinical Studies

1 Jan 2011

Abstract excerpt

The development of multidrug resistance (MDR) and subsequent relapse on therapy is a widespread problem in breast cancer, but our understanding of the underlying molecular mechanisms is incomplete. Numerous studies have aimed to establish the role of drug transporter pumps in MDR and to link their expression to response to chemotherapy. The ATP-binding cassette (ABC) transporters are central to breast cancer MDR,...

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PMID: 22332018
DOI: 10.4061/2011/967419

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