Article
Noninvasive molecular imaging to detect transgene expression of lentiviral vector in nonhuman primates.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 1 Jul 2006
Sander William E, Metzger Mark E, Morizono Kouki, Bonifacino Aylin, Penzak Scott R, Xie Yi-Ming, Chen Irvin S Y, Bacon Jeffrey, Sestrich Stephen G, Szajek Lawrence P, Donahue Robert E
Abstract excerpt
UNLABELLED: Noninvasive imaging of a reporter gene is a new and promising technique to quantify transgene expression after gene therapy. This study was performed to demonstrate visualization of lentiviral-marked cells by PET. METHODS: We transduced nonhuman primate CD34+ hematopoietic cells with a lentiviral vector expressing a PET reporter gene, the mutant viral herpes simplex virus type 1-thymidine kinase...
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