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Article

Multitracer positron emission tomographic imaging of exogenous gene expression mediated by a universal herpes simplex virus 1 amplicon vector.

Molecular imaging - 1 Jan 2000

Kummer Christiane, Winkeler Alexandra, Dittmar Claus, Bauer Bernd, Rueger Maria Adele, Rueckriem Benedikt, Heneka Michael T, Vollmar Stefan, Wienhard Klaus, Fraefel Cornel, Heiss Wolf-Dieter, Jacobs Andreas H

Abstract excerpt

To develop efficient and safe gene therapy approaches, the herpes simplex virus type 1 thymidine kinase gene (HSV-1-tk) has been shown to function as a marker gene for the direct noninvasive in vivo localization of thymidine kinase (TK) expression by positron emission tomography (PET) using radiolabeled nucleoside analogues as specific TK substrates. Moreover, the gene encoding dopamine type 2 receptor (d2r)...

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PMID: 17532884

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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