Article
Monitoring adenoviral DNA delivery, using a mutant herpes simplex virus type 1 thymidine kinase gene as a PET reporter gene.
Gene therapy - 1 Dec 2002
Liang Q, Nguyen K, Satyamurthy N, Barrio J R, Phelps M E, Gambhir S S, Herschman H R
Abstract excerpt
Current gene therapy protocols often suffer from an inability to monitor the site, level and persistence of gene expression following somatic DNA delivery. Herpes simplex virus 1 thymidine kinase (HSV1-tk) is currently under intensive investigation as a reporter gene for in vivo imaging of reporter gene expression. The presence of the HSV1-tk reporter gene is repetitively and non-invasively monitored by systemic...
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