Article
Wnt signaling regulates acetylcholine receptor translocation and synaptic plasticity in the adult nervous system.
Cell - 30 Mar 2012
Jensen Michael, Hoerndli Frédéric J, Brockie Penelope J, Wang Rui, Johnson Erica, Maxfield Dane, Francis Michael M, Madsen David M, Maricq Andres V
Abstract excerpt
The adult nervous system is plastic, allowing us to learn, remember, and forget. Experience-dependent plasticity occurs at synapses--the specialized points of contact between neurons where signaling occurs. However, the mechanisms that regulate the strength of synaptic signaling are not well understood. Here, we define a Wnt-signaling pathway that modifies synaptic strength in the adult nervous system by...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.