Article
Association of mutant TP53 with alternative lengthening of telomeres and favorable prognosis in glioma.
Cancer research - 1 Jul 2006
Chen Yu-Jen, Hakin-Smith Vicky, Teo Mario, Xinarianos George E, Jellinek David A, Carroll Thomas, McDowell David, MacFarlane Martin R, Boet Ronald, Baguley Bruce C, Braithwaite Antony W, Reddel Roger R, Royds Janice A
Abstract excerpt
The molecular basis for alternative lengthening of telomeres (ALT), a prognostic marker for glioma patients, remains unknown. We examined TP53 status in relation to telomere maintenance mechanism (TMM) in 108 patients with glioblastoma multiforme and two patients with anaplastic astrocytoma from New Zealand and United Kingdom. Tumor samples were analyzed with respect to telomerase activity, telomere length, and...
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