Article
Linkage exclusion mapping with bone size in 79 Caucasian pedigrees.
Journal of bone and mineral metabolism - 1 Jan 2006
Chen Xiang-Ding, Shen Hui, Recker Robert R, Deng Hong-Wen
Abstract excerpt
Bone size is an important risk factor of osteoporotic fractures and has strong genetic determination. However, genetic studies on bone size variation are relatively rare. In the present study, we conducted a linkage exclusion mapping for bone size variation on chromosomes 1, 4, 6, and 17 in 79 Caucasian pedigrees. For hip bone size variation, several genomic regions were excluded at effect sizes of 10% or...
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