V lambda and J lambda-C lambda gene segments of the human immunoglobulin lambda light chain locus are separated by 14 kb and rearrange by a deletion mechanism.

doi:10.1002/eji.1830210627

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Article

V lambda and J lambda-C lambda gene segments of the human immunoglobulin lambda light chain locus are separated by 14 kb and rearrange by a deletion mechanism.

European journal of immunology - 1 Jun 1991

Combriato G, Klobeck H G

Abstract excerpt

We have cloned a region of 124 kb of the human immunoglobulin lambda light chain locus on chromosome 22 encompassing seven V lambda and seven J-C lambda gene segments. No further C lambda gene segment was found in a region of 35 kb downstream of C lambda 7, which encodes the Ke+Oz- isotype. The C lambda proximal V lambda gene segment V lambda III. 1 is located 14.5 kb upstream of C lambda 1. The five sequenced V...

Topics

Amino Acid Sequence
Base Sequence
Chromosome Deletion
Chromosome Mapping
Cloning, Molecular
DNA
Gene Rearrangement
Genes, Immunoglobulin
Humans
Immunoglobulin Constant Regions
Immunoglobulin Joining Region

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Light Chains

Immunoglobulin Variable Region

Immunoglobulin lambda-Chains

Molecular Sequence Data

Mutation

Pseudogenes

Source

Open in PubMed

Identifiers

PMID: 1904362
DOI: 10.1002/eji.1830210627

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1904362-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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