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Article

Generation and maintenance of diversity in the cattle MHC class I region.

Immunogenetics - 1 Aug 2006

Birch James, Murphy Lisa, MacHugh Niall D, Ellis Shirley A

Abstract excerpt

Major histocompatibility complex (MHC) class I genes play a crucial role in the immune defence against intracellular pathogens. An important evolutionary strategy is to generate and maintain a high level of diversity in these genes. Humans express three highly polymorphic classical MHC class I genes (HLA-A, HLA-B and HLA-C). In contrast, some species, for example rat and rhesus macaque, maintain diversity by...

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Identifiers

PMID: 16807744
DOI: 10.1007/s00251-006-0137-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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