Article
Haplotype diversity generated by ancient recombination-like events in the MHC of Indian rhesus macaques.
Immunogenetics - 1 Aug 2013
Doxiadis Gaby G M, de Groot Nanine, Otting Nel, de Vos-Rouweler Annemiek J M, Bolijn Maria J, Heijmans Corrine M C, de Groot Natasja G, van der Wiel Marit K H, Remarque Edmond J, Vangenot Christelle, Nunes José M, Sanchez-Mazas Alicia, Bontrop Ronald E
Abstract excerpt
The Mamu-A, Mamu-B, and Mamu-DRB genes of the rhesus macaque show several levels of complexity such as allelic heterogeneity (polymorphism), copy number variation, differential segregation of genes/alleles present on a haplotype (diversity) and transcription level differences. A combination of techniques was implemented to screen a large panel of pedigreed Indian rhesus macaques (1,384 individuals representing...
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