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Article

Chromosomal Instability in Barrett's Esophagus Is Related to Telomere Shortening

1 Aug 2006

Abstract excerpt

Barrett's esophagus is a useful model for the study of carcinogenesis, as the metaplastic columnar epithelium that replaces squamous esophageal epithelium is at elevated risk for development of adenocarcinoma. We examined telomere length and chromosomal instability (CIN) in Barrett's esophagus biopsies using fluorescence in situ hybridization. To study CIN, we selected centromere and locus-specific arm probes to...

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Share to Epigenetics and DNA Methylation
Share to Esophageal Cancer Research and Treatment
Share to Telomeres, Telomerase, and Senescence

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PMID: 16896031
DOI: 10.1158/1055-9965.epi-05-0837

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Chromosomal Instability in Barrett's Esophagus Is Related to Telomere ShorteningPMID 16896031Read ↗

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