Article
Possible associations between successful aging and polymorphic markers in the Werner gene region.
Annals of the New York Academy of Sciences - 1 May 2006
Sild Mari, Koca Cemile, Bendixen Mette H, Frederiksen Henrik, McGue Matt, Kølvraa Steen, Christensen Kaare, Nexø Bjørn
Abstract excerpt
Werner syndrome (WS) is an autosomal recessive segmental progeroid syndrome caused by mutations in the Werner (WRN) gene leading to the early onset of many (but not all) aspects of normal aging. To investigate whether the WRN gene affects the course of aging in non-Werner syndrome individuals, we performed association studies analyzing several single nucleotide polymorphisms (SNPs) in the WRN locus. We found...
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